In a breakthrough that may lead to better diagnosis and treatment of Crohn’s disease, scientists from the University of Toronto have announced their discovery of a new Crohn’s gene. According to the scientists, the as yet undisclosed gene produces a protein that functions improperly in patients with the disease.

Although the researchers admit that it is not the only gene involved in the disease, they are now working on a chemical that could repair the protein. “There’s an urgent need for better treatment for patients with Crohn’s.” Stated Professor Katherine Siminovitch.

It is believed that between 400,000 and 600,000 people in North America suffer from Crohn’s disease. Treatments include medication in the form of nonsteroidal anti-inflammatories (NSAIDs) as well as TNF-a blockers. Some treatments also require hospitalization and surgery.

“If we can identify the majority of the genes involved in this disease, we can learn how these genes act together to cause disease. This information will help us identify potentially preventable environmental triggers as well.” Says Siminovitch.

References: BBC News, Scientists identify Crohn’s gene, April 13, 2004; Alimentary Pharmacology & Therapeutics, The epidemiology and natural history of Crohn’s disease in population-based patient cohorts from North America: a systematic review, January 2002; Spondylitis.org